Manaus Joins Quito, Cusco, Bariloche, La Paz, Medellín and Santiago as South America’s Must-Visit Cities for Nature Lovers Seeking Breathtaking Adventures!

Published on December 15, 2025

South America, a continent bursting with natural beauty, offers some of the most breathtaking landscapes on Earth. From lush rainforests to soaring mountains, expansive deserts to cascading waterfalls, nature enthusiasts have an endless array of destinations to explore. For travelers seeking to connect with the natural world, certain South American cities stand out not just for their urban charm but for their proximity to awe-inspiring natural wonders. Here’s a guide to seven cities in South America that should top the list for anyone who loves nature.

1. Manaus, Brazil – Gateway to the Amazon Rainforest

Nestled deep in the heart of Brazil, Manaus serves as the main gateway to the Amazon Rainforest, the largest tropical rainforest in the world. Despite being a bustling city of over two million people, Manaus feels like a portal to the wild. The city itself boasts impressive landmarks such as the Teatro Amazonas, an opera house built during the rubber boom era, but the real draw is the surrounding jungle.

From Manaus, visitors can embark on river cruises or guided jungle treks to spot rare wildlife, including pink river dolphins, jaguars, and an array of exotic birds. Ecotourism lodges along the Amazon River offer immersive experiences where travelers can learn about indigenous cultures and witness the rainforest’s astounding biodiversity. The best time to visit is during the dry season (July to December) when wildlife is easier to spot and river levels are lower, making hiking trails more accessible.

2. Quito, Ecuador – The Andean Jewel

Quito, Ecuador’s capital, is perched at an altitude of 2,850 meters in the Andes Mountains. Its historic center, a UNESCO World Heritage site, is a stunning mix of colonial architecture and vibrant plazas. But for nature lovers, Quito’s true appeal lies in its surroundings.

The city is a perfect base for exploring the nearby Andean peaks, volcanoes, and cloud forests. A short drive from Quito leads to the famous Cotopaxi National Park, home to one of the world’s highest active volcanoes. Adventure seekers can hike, mountain bike, or even horseback ride across the dramatic landscapes. Additionally, the nearby Mindo Cloud Forest offers an enchanting experience for birdwatchers, with hundreds of species, including toucans, hummingbirds, and the elusive Andean cock-of-the-rock. Quito combines urban culture with a gateway to some of the most striking natural environments in South America.

3. Cusco, Peru – In the Shadow of the Andes

Often described as the historical capital of the Inca Empire, Cusco is a city where history and nature intertwine seamlessly. The city itself, at an altitude of around 3,400 meters, is an architectural marvel, blending Inca walls with Spanish colonial buildings. Yet the true allure for nature enthusiasts is just beyond the city limits.

Cusco serves as the starting point for treks into the Sacred Valley and, of course, the iconic Machu Picchu. The Inca Trail, a multi-day trek through mountainous terrain, cloud forests, and alpine meadows, is a bucket-list experience for anyone who loves nature. Additionally, nearby areas such as Sacsayhuamán, Pisac, and Ollantaytambo offer stunning mountain views, vibrant flora, and the chance to witness ancient terraces that harmonize with the natural landscape. Visiting Cusco allows travelers to combine rich cultural experiences with unparalleled encounters with nature.

4. Bariloche, Argentina – Lake District Paradise

Nestled in the foothills of the Andes in Argentina’s Patagonia region, San Carlos de Bariloche is often called the “Swiss of South America” due to its alpine architecture and scenic surroundings. Bariloche is famous for its pristine lakes, snow-capped mountains, and dense forests, making it a haven for outdoor enthusiasts.

In winter, Bariloche becomes a skiing paradise, but during the warmer months, the region offers hiking, kayaking, and cycling opportunities. The Nahuel Huapi National Park, which surrounds the city, is home to glacial lakes, rivers, and diverse wildlife including guanacos, condors, and foxes. Bariloche’s natural beauty is complemented by charming chocolate shops and lakeside cafés, offering a perfect blend of relaxation and adventure. For travelers who appreciate stunning landscapes with abundant recreational activities, Bariloche is a must-visit destination.

5. La Paz, Bolivia – High-Altitude Natural Wonders

Perched at roughly 3,650 meters above sea level, La Paz is the highest administrative capital in the world and a city where urban life meets dramatic natural scenery. The city sits in a deep canyon carved by the Choqueyapu River, with the majestic Illimani Mountain towering in the background, visible from nearly every part of the city.

Nature lovers will find plenty to explore in and around La Paz. The nearby Valle de la Luna (Moon Valley) features otherworldly rock formations created by years of erosion, resembling a lunar landscape. For those seeking adventure, the Yungas Road, famously known as the “Death Road,” offers thrilling cycling experiences through dense cloud forests and deep valleys. La Paz also serves as a base for visiting Lake Titicaca, the world’s highest navigable lake, with its serene waters and floating reed islands inhabited by the Uros people. The combination of high-altitude landscapes and cultural richness makes La Paz an exceptional destination for nature enthusiasts.

6. Medellín, Colombia – City of Eternal Spring Surrounded by Nature

Medellín, once known for its turbulent past, has reinvented itself as a vibrant and innovative city, earning the nickname “City of Eternal Spring” due to its year-round pleasant climate. Beyond its urban appeal, Medellín is surrounded by lush mountains and verdant valleys, offering countless opportunities for nature lovers.

Just outside the city, travelers can explore the Arví Park, an ecological nature reserve that provides hiking trails, birdwatching, and guided tours through tropical forests. The nearby coffee region, known as the Eje Cafetero, features rolling hills, coffee plantations, and picturesque landscapes ideal for trekking and photography. Medellín’s combination of urban culture, green spaces, and proximity to Colombia’s natural wonders makes it a perfect destination for those seeking a balance between city life and outdoor adventures.

7. Santiago, Chile – The Andes at Your Doorstep

Chile’s capital, Santiago, offers a unique blend of urban sophistication and immediate access to stunning natural landscapes. Located in a valley surrounded by the Andes Mountains, Santiago is a city where hikers, skiers, and outdoor enthusiasts can easily escape the metropolitan bustle.

Just a short drive from the city, visitors can explore the Cajón del Maipo, a spectacular canyon offering hiking, rafting, and hot springs. In winter, the nearby ski resorts of Valle Nevado and La Parva attract winter sports enthusiasts, while summer offers countless trekking opportunities in the high Andes. Additionally, Santiago serves as a gateway to Chile’s diverse ecosystems, including the nearby vineyards, coastal areas, and national parks. For travelers who want to combine city life with access to mountains, rivers, and valleys, Santiago is a natural choice.

Tips for Nature Lovers Traveling in South America

Traveling in South America to enjoy nature can be an unforgettable experience, but it requires some planning. Here are a few tips:

1. Altitude Awareness: Cities like Cusco, La Paz, and Quito are at high altitudes. Travelers should acclimate gradually to avoid altitude sickness. Hydration, light activity on the first day, and avoiding alcohol can help.
2. Best Seasons to Visit: The continent spans diverse climates, so research local seasons. For instance, the Amazon is best visited during the dry season, while Patagonia offers summer hikes from December to February.
3. Sustainable Travel: Many destinations are ecologically sensitive. Choose eco-lodges, respect wildlife, and minimize plastic use to preserve natural habitats.
4. Local Guides: Hiring knowledgeable local guides enhances the experience, providing insights into flora, fauna, and cultural connections with nature.
5. Packing Essentials: Bring appropriate clothing for both city and outdoor activities. Layers, sturdy hiking shoes, rain gear, and sun protection are essential for most South American natural destinations.

Conclusion

South America offers a spectacular variety of landscapes, from dense rainforests to towering mountains, serene lakes to rushing rivers. For travelers who love nature, cities like Manaus, Quito, Cusco, Bariloche, La Paz, Medellín, and Santiago are more than just urban centers—they are gateways to the continent’s most breathtaking natural wonders. Each city provides a unique experience, combining cultural richness with opportunities to immerse yourself in stunning ecosystems.

Whether you’re trekking through Andean peaks, exploring tropical jungles, or relaxing by glacial lakes, South America promises an adventure for every nature enthusiast. Planning carefully, respecting the environment, and embracing local cultures ensures a journey that is not only memorable but also meaningful. For anyone looking to reconnect with nature, these seven cities are essential stops on the South American itinerary.