US, Mexico, Costa Rica, Guatemala, El Salvador, and Panama Voyage with Holland America Experience the Ultimate Escape to Exotic Shores and the Legendary Panama Canal

Published on September 2, 2025

Holland America’s US, Mexico, Costa Rica, Guatemala, El Salvador, and Panama Voyage offers the ultimate escape, taking travelers on an unforgettable journey through some of Central America’s most exotic and culturally rich destinations. This 22-day adventure offers a unique opportunity to explore the vibrant shores of Mexico, Costa Rica’s lush rainforests, Guatemala’s historic beauty, El Salvador’s hidden gems, and Panama’s awe-inspiring landscapes. The highlight of the voyage is the legendary Panama Canal, where guests will witness one of the greatest engineering marvels of the modern world. This cruise combines relaxation, adventure, and cultural discovery, making it the perfect getaway for those seeking a transformative travel experience.

This highly anticipated itinerary has seen a slight reduction in price compared to earlier this year, making it even more appealing for those seeking a memorable getaway.

However, the departure date is fast approaching, with the cruise setting sail from Vancouver’s Canada Place on October 5 at 7 a.m., though it officially begins in Seattle on October 4. Travelers interested in boarding from Vancouver should contact the cruise line directly, as the option may not appear in online searches.

After two days at sea, the ship will visit Santa Barbara and San Diego, California, allowing passengers about eight hours in each port. Those not wishing to disembark can remain on the ship, as only two U.S. stops are scheduled, excluding the final disembarkation point in Fort Lauderdale.

Following this, the cruise will head south to the vibrant resort town of Puerto Vallarta, Mexico, for a day of exploration. A day at sea precedes stops in Huatulco and Puerto Chiapas, Mexico, both offering stunning coastal views and local culture.

Next on the itinerary is a visit to Puerto Quetzal in Guatemala, followed by Acajutla in El Salvador. After a day at sea, the ship will dock in Puntarenas, Costa Rica, where passengers can immerse themselves in the region’s lush tropical rainforest.

The highlight of the journey is a full transit of the Panama Canal, a true marvel of engineering. From there, the ship will sail on to Aruba, an island renowned for its beautiful beaches, luxurious resorts, and crystal-clear waters teeming with coral reefs and flamingos.

The cruise concludes in Fort Lauderdale, Florida, on October 26. This 22-day adventure (21 days from Vancouver) promises an unforgettable exploration of Central America and the Caribbean.

For those unable to commit to a three-week holiday this fall, this itinerary could serve as inspiration for future travel plans.

Cruise Itinerary

Pricing Overview

The cost for an interior cabin for two passengers is \$6,376.62, which works out to \$3,188.31 per person. This equates to approximately \$144.91 per person per day. The price covers meals, entertainment, accommodation, and transportation. However, it does not include specialty dining, alcohol, excursions, Wi-Fi, or gratuities.

Earlier this year, the same interior cabin was priced at \$6,843.58, or \$3,421.79 per person, which amounted to about \$162.94 per person per day. As the departure date nears, the price for interior cabins may decrease further, although availability is becoming more limited. Oceanview cabins are available from \$200 per person.

Flights from Fort Lauderdale to Vancouver have also become more affordable, with options starting as low as \$190, departing at 2 p.m. from Fort Lauderdale-Hollywood International Airport (FLL) to Vancouver International Airport (YVR). Evening flights may offer added security in terms of travel timing.

Holland America’s US, Mexico, Costa Rica, Guatemala, El Salvador, and Panama Voyage offers the ultimate escape, exploring vibrant shores, lush rainforests, and the legendary Panama Canal. This 22-day adventure combines cultural discovery, relaxation, and awe-inspiring landscapes.

In conclusion, Holland America’s Ultimate 22-Day Mexico, Costa Rica, Guatemala, El Salvador, and Panama Cruise offers a unique opportunity to explore some of the most stunning and culturally diverse destinations in Central America. With the iconic Panama Canal as the centerpiece, this journey promises an unforgettable experience filled with adventure, relaxation, and discovery. Whether you’re seeking vibrant city life, lush natural landscapes, or breathtaking coastal beauty, this cruise delivers it all, making it the perfect choice for travelers looking to embark on a once-in-a-lifetime adventure.