American Cruise Lines Launches Exciting 2025 Mississippi River Itineraries

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American Cruise Lines is gearing up to launch its 2025 Mississippi River cruising season, starting February 21. The award-winning American Serenade will set sail on the classic 9-Day Lower Mississippi River Cruise, navigating from New Orleans, Louisiana, to Memphis, Tennessee. The new season promises an exciting lineup of itineraries, including the debut of a 12-Day Mississippi Explorer Cruise and exclusive journeys along the Tennessee, Cumberland, and Ohio Rivers. Notable highlights include the 16-Day Grand Ohio River Cruise (Pittsburgh, Pennsylvania, to St. Louis, Missouri) and two monumental extended cruises: the 51-Day Great United States Cruise and the 36-Day Civil War Battlefields Cruise.

Unparalleled River Cruising

American Cruise Lines stands out as the only river cruise operator offering both classic paddlewheelers and modern riverboats, ensuring a unique and personalized experience. With vessels designed to be smaller than standard riverboats, travelers enjoy a more intimate journey along America’s legendary waterways.

Must-See Attractions:

• Historic landmarks: Visit iconic sites like Elvis Presley’s Graceland and Mark Twain’s boyhood home.
• Adventure-filled excursions: Enjoy Cajun swamp safaris, ATV treks, and more.
• Cultural explorations: Marvel at landmarks like the St. Louis Arch and Vicksburg National Military Park while delving into the music, cuisine, and history of the region.

Additionally, the 2025 season features themed and holiday cruises, ranging from Mark Twain and Culinary cruises to Civil War, Christmas, and a National Parks Cruise spotlighting Great Smoky Mountains National Park.

Featured 2025 Mississippi River Cruises

• 8-Day Historic Mississippi River Cruise (Roundtrip from New Orleans, LA)
• 9-Day Lower Mississippi River Cruise (Memphis, TN to New Orleans, LA)
• 9-Day Upper Mississippi River Cruise (St. Louis, MO to St. Paul, MN)
• 9-Day Music Cities Cruise (Memphis to Nashville, TN)
• 9-Day Tennessee Rivers Cruise (Nashville to Chattanooga, TN)
• NEW: 12-Day Mississippi Explorer Cruise (Memphis, TN to New Orleans, LA)
• 12-Day Mississippi River Gateway Cruise (New Orleans, LA to Louisville, KY)
• 9-Day Ohio River Cruise (Louisville, KY to Pittsburgh, PA)
• NEW: 16-Day Grand Ohio River Cruise (Pittsburgh, PA to St. Louis, MO)
• 12-Day Great Smoky Mountains National Park Cruise (Knoxville to Nashville, TN)
• 16-Day Grand Heartland Cruise (St. Paul, MN to New Orleans, LA)
• 23-Day Complete Mississippi River Cruise (New Orleans, LA to St. Paul, MN)
• NEW Extended Cruises:
  • 51-Day Great United States Cruise
  • 36-Day Civil War Battlefields Cruise

All-Inclusive Amenities

American Cruise Lines ensures a seamless experience with thoughtfully curated inclusions:

• Pre-cruise hotel accommodations.
• Enrichment programs and onboard entertainment.
• Shore excursions and private transportation.
• Gourmet dining, Wi-Fi, complimentary cocktails, and more.
• Fares that include tips, gratuities, port charges, and fees.

Guests can also benefit from flat-rate domestic airfare options, with select itineraries offering complimentary airfare.

Recognized Industry Leader

American Cruise Lines continues to set the gold standard for river cruising, earning prestigious accolades such as:

• Cruise Critic’s 2024 Best for Solo Travelers Award.
• Travel Weekly’s 2024 Magellan Award for Best Mississippi River Cruises.
• USA Today’s 2025 10Best Awards for Best River Cruise Line, Best Alaska Cruises, Best Boutique Cruise Line, and Best Shore Excursions.

Set sail with American Cruise Lines and explore the heart of the United States, where history, culture, and scenic beauty converge on its iconic rivers.